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纳米载体直击患病细胞 - China Medical Device Manufacturer
CMDM

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Wed, January 17th, 2018

2005 秋季刊 » 技术新知
纳米载体直击患病细胞

纳米载体就是给药装置的未来吗?新加坡的研究人员正在研制新的给药装置,这种装置可在不影响正常细胞的前提下将抗癌药物传输至目标癌细胞。他们希望这样可以减少化疗的不良副作用,例如:恶心、虚弱和脱发。该研究小组希望这项技术也可以用于其他疾病的治疗。

新加坡生物工程与纳米科技研究院 (IBN) 药物传输、蛋白质与基因研究计划的主管 Yang Yi-Yan 博士说:要想使毒性药物仅杀伤患病细胞而不杀伤正常细胞,需要一种具有药物导向功能的给药装置,经过一定的提纯后,我们这种纳米载体可以广泛应用于各种药物传输 。

这一技术需要用一种外壳将生物活性复合物包装起来。这种外壳使里面的复合物与体液隔绝,防止降解。由于该纳米载体对温度和酸碱度敏感,因此它可以探测出癌组织中典型的酸性环境。发现癌组织后,纳米载体会形成一个疏水外壳,并借此粘附到肿瘤上。它们可通过连接外壳的生物信号聚集在肿瘤上。随后,纳米载体吸收细胞质,并释放出药物。

Yang 说,虽然在不损伤周围正常细胞的前提下治疗患病细胞可扩展到各种用途,但是需要改变装置。要想将这种纳米载体应用于其他疾病例如炎症组织-的药物传输上,需要将一种新的生物信号结合到纳米载体的表面,以便使药物认准患病组织或细胞。

IBN 的目前方法尚未显示出明显的细胞毒性。同时,研究人员指出,使用纳米载体装载抗癌药阿霉素时,其抑制肿瘤生长的作用强于单独使用阿霉素。


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