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研究人员再度确立医学成像金标准 - China Medical Device Manufacturer
CMDM

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Wed, January 17th, 2018

2006年1/2月刊 » 行业新闻
研究人员再度确立医学成像金标准

激光照明金纳米棒技术将超灵敏医学成像技术带入一个空前的灵敏水平。该技术将微小金棒注射入血管,透过皮肤用激光来照亮它们。在动物实验中,利用此方法生成的图像比传统荧光染料法明亮得多。Purdue大学(美国印第安娜州, W. Lafayette)的研究员已在10月20日将此发现刊登在PNAS在线杂志(www.pnas.org)上。

在活体小鼠血管中拍摄的金纳米棒发出红色光。美国Purdue大学所做的研究可能开创一种新型超灵敏医学成像技术。

一个纳米棒大约长60纳米,宽20纳米,比红血球小200倍。研究人员将其注入小鼠,并在其流经血管时拍摄了结构图像。纳米棒比单个若丹明分子发出的双光子荧光要亮58倍。(若丹明普遍用于观察细胞及分子的内部机制。) 据研究者称,该技术克服了当前在使用光分析血管及皮下组织时遇到的问题。

参加该项研究的化学副教授Alexander Wei说:可见光谱范围的光源不容易穿透组织。他提出在近红外光谱的可见范围外利用激光脉冲可完善成像方法,他解释道:在近红外范围有一个区段-波长大约800至1300纳米-可以控制用来发展全新的成像技术。用该波段区的光线照射时,特定长宽比的小金棒会明亮发光。

据Wei介绍,要早期检测到病变的细胞,具有单微粒水平灵敏度的可靠技术是十分重要的。他表示:金纳米棒显示了Ji-Xin Cheng (生物医学工程助理教授及研究人员)发现的非线性成像法可以达到这一检测水平。

该研究论文题为In Vitro and In Vivo Two-Photon Luminescence Imaging of Single Gold Nanorods, 可在www.pnas.org购得。


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