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微型显微镜可拍摄清晰的脑内图像 - China Medical Device Manufacturer
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Fri, January 19th, 2018

2006年7/8月刊 » 技术新知
微型显微镜可拍摄清晰的脑内图像

斯坦福大学(美国加州,Palo Alto;www.stanford.edu)的一个生物研究小组发明了微型显微镜,可以观察老鼠的大脑活动。该技术将可用于脑部肿瘤成像和神经元活动的拍摄。

由Mark Schnitzer领导的生物研究小组,已经通过该显微镜观察了老鼠大脑皮层下方几毫米处的血管。他们希望这种称为微型内窥镜的微型显微镜,同样可用于脑细胞的观察。参与该项目的一位研究生Ben Flusberg说,该小组通过压电电机缩小了整个设备的体积。

宾夕法尼亚大学的生物物理学家Britton Chance说:微型内窥镜是一件微观力学和微电子学的杰作。

该设备重3.9g,分辨率达1m。这种微型内窥镜被安放在一根1mm探头的末端,然后通过在被麻醉的小鼠头上钻一个小孔插入脑内。该设备通过近红外线对事先注射了荧光标记物的血管进行照明。探头可以采集血管发出的光线,并记录在微型内窥镜中。血管图像可在计算机屏幕上观看。但是,该设备无法精确定位血管的位置,因此也就无法知道探头所拍摄图像的准确位置。

该设备的未来应用还可能包括:将显微镜插入清醒状态的动物脑中并拍摄神经元的活动以及进行脑肿瘤成像。

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