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水凝胶在医疗器械应用大有前景 - China Medical Device Manufacturer
CMDM

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Wed, January 17th, 2018

2007 夏季刊 » 技术新知
水凝胶在医疗器械应用大有前景

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美国印第安那州Purdue大学的副教授Alyssa Panitch手上的有机化合物样本能在注入人体后迅速固化。
美国印第安那州Purdue大学的研究人员最近发现了一种多糖水凝胶,注入身体后会固化,可为损伤的骨骼、血管以及其他组织提供支撑。一旦注入身体,这种水凝胶就会形成一种三维基质,可刺激躯体自身组织的生长,并且最终会自行分解,可用于制造如药物洗脱支架等医疗器械。Purdue大学生物医学工程系副教授Alyssa Panitch表示,由于这种材料可以抑制血块的形成以及释放抗增生的药物,它会使药物洗脱支架更有效。

这种水凝胶之所以能形成三维基质,是得益于肝素多糖以及抗凝血酶III蛋白分子中一段多肽的自然交互作用。凝胶聚集速度非常快,基质可形成任何需要的形状。将水凝胶注射到骨头缺损处,它将迅速固化,填补缺损,并释放骨形成蛋白以促进愈合。

这项发现源于一项对肝素结合性生长因子缓释控制组分的研究。研究员偶然发现,多糖可与细胞外基质中蛋白的某些多肽序列发生反应,形成凝胶样物质。通过控制多肽与多糖连接的强度,开发出一种能在指定时间内缓释治疗性多肽的凝胶,一经加热,凝胶就会从固态变回液态,冷却时作用恰恰相反。这种特性对缓释性药物很重要。

当凝胶用于药物或生长因子的缓释治疗时,可协助伤口愈合和骨骼再生。在凝胶内加入抑制炎症和促进生长因子分泌的治疗成分,并在脊髓损伤后的几小时内注射,对预后很有帮助。研究人员希望这项技术能在2-3年内应用到人体上。


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