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新型复合物可杀灭病毒及耐抗生素细菌 - China Medical Device Manufacturer
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Sat, January 20th, 2018

2007 夏季刊 » 行业新闻
新型复合物可杀灭病毒及耐抗生素细菌

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一种新型的复合物未来有可能作为各种植入式医疗器械的抗菌涂层。由位于美国丹佛市的Ceragenix Pharmaceuticals公司(www.ceragenix.com)提供的Ceragenin复合物带有净正电荷,使其能够通过静电吸附于特定病毒、真菌和细菌带负电的细胞膜上。微生物一旦接触该药物就会迅速死亡,其作用机制类似于人体内自然产生的抗菌肽,能有效抑制对传统抗生素耐药的细菌。

一项持续21天的研究证明了该药物的有效性。研究中,经Ceragenin处理的聚氨酯导管每天用磷酸盐缓冲溶液浸泡。在研究的最后一天,使导管接触100万个菌落形成单位的耐甲氧西林金黄色葡萄球菌接种体,以激发免疫反应。处理过的导管表面吸附的菌落形成单位不到100个,而未处理的对照组覆盖有30000个细菌。

Ceragenix主席及首席执行官Steven S. Porter说:该研究证明了Ceragenin用于植入性医疗器械抗菌处理的潜力。这一复合物会有广泛的临床及工业应用价值。 该药物的发明者、位于美国犹他州Brigham Young大学的教授Paul Savage也说:此技术的独特性和其特殊的分子结构不仅对植入性医疗器械的涂层有助益,还可以用于手术帷帘、墙壁覆盖物等等。

位于美国田纳西州Vanderbilt大学的一项体外研究也表明该药物有杀灭多种HIV毒株的能力。根据目前观察,该药物对人体上皮细胞并未显示有毒性作用,但可以阻止HIV膜粘附到细胞上进行复制。其它的预试验也显示该复合物在流行性感冒、禽流感、疱疹及天花中有抗病作用。


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