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利用人工静脉瓣改善血流状况 - China Medical Device Manufacturer
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Wed, January 17th, 2018

2009年1月CMDM电子快讯 » 技术新知
利用人工静脉瓣改善血流状况

David Ku在乔治亚理工学院领导了一项利用人工静脉瓣治疗慢性静脉功能不全的研究。

乔治亚理工学院(Georgia Tech; 美国乔治亚州,亚特兰大; www.gatech.edu)的工程师们研制出一种可治疗慢性静脉功能不全(即静脉瓣无法保证血液单向流动、返回心脏)的人工静脉瓣。

“血液在重力作用下流向脚趾,而人体会通过静脉瓣使血液沿一个方向流回心脏,”乔治亚理工学院的机械工程学教授David Ku解释说。Ku教授介绍说,在凝血作用影响下静脉瓣会发生崩解,导致血流方向异常,最终导致腿部肿胀。Ku教授领导的研究小组研制出一种人工静脉瓣,可以替换结构受损、丧失功能的静脉瓣。研究人员在生物材料学会秋季研讨会上展示了该人工静脉瓣的设计并公布了实验室研究结果。

医生为慢性静脉功能不全患者指定的治疗方案通常包括服用抗凝药、卧床休息和穿戴加压长袜,所有这些治疗都是治标不治本。受损的静脉瓣有时能够修复,但当静脉瓣无法修复时,可通过一些外科手术(如静脉瓣移植)更换深部静脉瓣。而用人工静脉瓣进行替换可能是一种更好的办法,因为在患者腿部找到合适的供体瓣膜绝非易事,Ku教授介绍说。 “以往研究表明即使找到了供体瓣膜,这种植入手术也会对患者腿部造成严重创伤,”Ku教授补充道(Ku教授拥有机械工程学和医学博士学位)。“为了避免这些并发症,人们之前设计了一些人工静脉瓣,但大都没什么临床应用价值。”

Ku教授和同事相信他们研制的静脉瓣能够克服以往的难点。这种单向瓣膜由聚乙烯醇低温凝胶制成,这种凝胶是由乔治亚理工学院于1999年发明的一种专利材料。该材料具有生物相容性,机械强度可调,弹性与人体组织相当。

研究人员已于10月份开始利用羊进行人工静脉瓣原型产品的临床前动物实验,测试其体内生物相容性及性能。之所以选择羊作为实验动物,是因为羊心血管系统的构造和生理特性均与人相近。


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