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通过二极管将PET-MRI扫描融为一体 - China Medical Device Manufacturer
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Wed, January 17th, 2018

2009年1月CMDM电子快讯 » 技术新知
通过二极管将PET-MRI扫描融为一体

MAPD光子计数装置可减少对PMTs的需求,提高医疗成像能力。

到目前为止,诸如正电子发射断层摄影(PET)等医疗成像技术仍旧需要大量昂贵的光电倍增管(PMTs)。但是这种日子可能就要结束了。Zecotek Photonics Inc.公司(加拿大不列颠哥伦比亚省,温哥华;www.zecotek.com) 研制出一种二极管产品,据说可减少对PMTs 的需求,提高医疗成像能力。

该产品被称为微像素雪崩光电二极管 (MAPD),是一种由多个独立的雪崩光电二极管并联而成的光子计数装置。MAPDs能够探测到极微小的信号,具有通常只有PMTs才能达到的极高增益(~106),同时只需使用不到100 V的电源。“MAPDs的主要优点是与PMTs体积巨大、需要高压电源相比,MAPDs体积非常小,电源要求低,” Zecotek公司首席技术官(CTO)Stephen Rowe说道。此外,高密度微像素可确保装置在很大的输入信号动态范围内具有很高的响应线性,从而实现对少量或大量入射光子的准确计数。“产品极高的时间分辨率使我们能够对飞行时间进行准确的测量,并提高响应的光子事件绘图精度,”Rowe补充道。

Zecotek公司目前正在与华盛顿大学联合开发一种基于MAPD技术和精细硅酸镥(LFS)闪烁晶体材料的PET-MRI扫描仪。开发PET 、MRI集成式扫描设备的核心难点在于MRI的强磁场,这个强磁场可破坏PET扫描仪的光电探测能力。由于真空管式PMTs内的电子路径较长,因此易受磁场影响。与此相反,由于MAPDs半导体由独立的小型P-N连接组成,MRI的磁场不会影响其载波通路。

集成式PET-MRI扫描设备将具有几大优点,Rowe解释道:“MRI能够对软组织进行高分辨率、高对比度的形态学成像。PET可对分子和代谢数据进行评价,但无法提供解剖数据。集成式PET-MRI系统则可同时采集上述数据。”这种集成式技术将提高诊断准确性,与PET-CT系统相比减少辐射暴露量,提高患者检查速度,有利于恶性肿瘤的早期发现。

MAPD的生产前测试已于2008年4月份完成,将于2009年第一季度开始大规模生产。最初将生产包含64个MAPDs、按照8 8格式排布的产品,每个尺寸均为3 3 mm。这种64芯MAPD阵列可与LFS闪烁晶体配合使用,应用于多种医疗扫描技术中。此外,研究人员还在优化8 8阵列封装技术,使其成为其他产品配置的设计参考或标准。


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