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生物吸收性聚合物实现局部给药 - China Medical Device Manufacturer
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Wed, January 17th, 2018

2009年2月CMDM电子快讯 » 技术新知
生物吸收性聚合物实现局部给药

By: Stephanie Steward

聚合物与药物混合后,可制成具有局部药物释放功能的可吸收植入器械。

由于复合产品的不断发展,植入物不仅可按时在体内消失,而且这些植入物现在还能以预定的速度释放药物。此类产品的发展过程中,生物相容性材料的日益增多发挥了重要作用。而合约流程开发和制造商Foster Corp.公司旗下的Foster Pharma公司(美国康涅狄格州,Putnam;www.fostercorporation.com),开发出一种定制式可吸收给药配方,将这些技术提升到新的水平。

Foster公司的配方将聚合物与药物混合,并将此聚合物加工成具有药物释放功能的植入器械。该聚合物采用先进的熔融挤出技术在7级制药净室内加工而成。这种熔融挤出工艺可确保药物活性成分分散到整个聚合物基质中。药物会随着这些材料逐渐为人体所吸收,慢慢释放出来。

Foster Pharma公司总裁Dan Lazas解释说:“既能实现诸如生物相容性植入物等短期机械功能,又能作为一种长期给药设备的复合产品,是生物吸收材料技术的延伸,近年来该技术备受关注。生物吸收性材料越来越受到器械设计人员的欢迎,与以往相比,该材料的使用正交叉渗透到业内更多领域。”

Lazas表示,该公司不仅生产用于加工注塑植入物的混合聚合物颗粒,还能生产可吸收药物洗脱纤维、杆材和薄膜。而且由于采用可吸收材料,因此无需通过手术取出植入物,这对病人来说大有益处。

从药物和生产两方面来看,开发这些产品也有许多好处。Lazas表示:“通过药物洗脱植入物的方式实现局部给药,可减少全身给药可能引发的不良反映,因为采用全身给药时,无需治疗的机体部分亦会受到影响。”这种定制配方工艺的特点包括药物控释以及调控植入物降解时间、抗张强度及其他具体应用特性。而且由于药物活性成分混合在聚合物内,因此无需额外涂层加工。


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