~ ~ ~
Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 60

Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 60

Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 60

Warning: mktime() [function.mktime]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 60

Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 61

Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 62

Deprecated: Function ereg_replace() is deprecated in /var/www/custom/archive.cmdm/article.php on line 102
利用表面工程技术控制生物膜形成 - China Medical Device Manufacturer
CMDM

- English | 中文

Fri, January 19th, 2018

2009年3月CMDM电子快讯 » 技术新知
利用表面工程技术控制生物膜形成

图中显示导管上形成的金黄色葡萄球菌生物膜。图片来源: 美国疾病预防控制中心

美国Syracuse大学的科学家通过研究细菌在压花金表面上的生长状况进一步了揭示了细菌性生物膜的形成机制。Yan-Yeung Luk、Dacheng Ren两位助理教授与同事利用表面工程技术有效抑制了生物膜的形成。通过之前的研究工作,Ren领导的研究小组发现生物膜很容易在包有甲基末端硫醇单分子层的金表面上生长。随后,他们用一种大家熟知的人造甜味剂——D-甘露醇替换甲基,发现此时的涂层可抑制生物膜的形成。另外,研究人员还将不利于生物膜生长的硫醇围绕适合生物膜生长的硫醇,构建出一种特殊的表面,使生物膜能够垂直生长,而不是水平向外生长。

虽然该材料表面并非第一种可抑制生物膜形成的表面,但其作用时间却是其他任何材料都无法比拟的。研究人员开发的这种表面抑制生物膜生长的作用可持续26天之久。“据我们所知,此前还没有哪种化学物质对压花表面上生物膜的形成有如此强度的抑制能力,”Ren说道。

美国堪萨斯大学药物化学教授Blake Peterson对该材料寄予厚望。“这种表面长期抑制生物膜的作用十分显著,可以此为基础开发性能更好的医疗植入物,例如:支架、分流器、假体以及导管,以免植入物功能受到生物膜相关性感染的不利影响,”Peterson说道。

(点击放大)

耐甲氧西林金黄色葡萄球菌(MRSA)等细菌形成的生物膜被认为是院内感染的主要致病因素。“与游离状态的细菌相比,生物膜上互相连接的细菌极其难以清除,因为这些细菌可耐受比常规剂量高1000倍的抗生素和消毒剂,”Ren解释说。“要防止生物膜形成并有效清除已经形成的生物膜,必须充分认识生物膜的形成机制。”


版权所有 © 2005-2010 医疗设计和制造OEM (CMDM) 本网站所有内容,如未获书面同意,不得以任何形式转载和节录。违反上述声明者,我方将依法追究法律责任。

本期其他技术新知

相关文章

- 主页 | 当期杂志 | 订阅 | 联系方式 | 关于我们 -©2011 汇科传讯集团 医疗设计和制造OEM 版权所有.