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计算模型可预测药物洗脱支架性能 - China Medical Device Manufacturer
CMDM

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Wed, January 17th, 2018

2009年4月CMDM电子快讯 » 技术新知
计算模型可预测药物洗脱支架性能

By: Shana Leonard

54980.tif
支架设计会影响药物在动脉血管内的分布,这是因为支架造成的血流变化会改变更易形成血凝块的药物集中区域。药物含量按颜色区分,蓝色表示低浓度,红色表示高浓度。

由于有研究指出药物洗脱支架与无包覆材料金属支架相比,更易出现血凝块且更易引发心脏病等副作用,因此自2003年第一款药物洗脱支架 (DES) 在美国获准使用以来,它一直是争论的焦点。麻省理工学院(MIT;马萨诸塞州剑桥;http://hst.mit.edu)的研究人员开发出一种数学模型可通过深入探究更安全的药物洗脱支架的设计,平息上述争论。

麻省理工学院健康科学技术学院教授Elazer Edelman、Thomas D.和Virginia W. Cabot与他们的同行Brinda Balakrishnan、Vijaya Kolachalama和Abraham Tzafriri研究员一起利用计算流体力学和传质模型,发现药物洗脱支架的设计及流动环境对其性能具有很大影响。麻省理工学院的研究人员证明血管内药物洗脱支架的体积及形状最终可影响血流和药物在体内的分布。

Edelman说,支架可改变其所在动脉血管壁的天然形状,从而改变动脉血流。血液流经支架的通路随后又可对药物在动脉血管壁上的沉积和滞留造成影响。他简单地描述了设计对支架性能的影响,“支架改变血液流动,血流改变药物释放,药物释放影响沉积效果,血流还能改变药物滞留。这种级联效应会影响人体对支架的反应。”

麻省理工学院的研究小组同时发现支架设计和尺寸是影响因血液流经支架形成之药物池的体积的关键因素。支架在动脉血管内引起血流分隔和再循环,形成抗再狭窄药剂的集中,据信这会导致血凝块。Edelman表示,考虑到上述因素,局部药物含量极高的支架更易引起血凝结。

以支架设计为基础,利用计算模型预测支架性能及动脉血流的变化有助于开发更安全的药物系统器械。Edelman指出它还能为工程师提供一种在支架开发初期对其设计改进的潜在影响进行评估的方法。他说:“该模型第一次使人们可以在测试支架之前观察其变化,这意味着可在不耗费时间、风险以及人体临床试验或动物实验花费的情况下,对大量设计改进进行高通量测试。”

Edelman表示,下一阶段研究将重点检查疾病模型,以了解血管壁的功能。他指出这一项目亦可采用相同的技术建模。


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