~ ~ ~
Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 60

Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 60

Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 60

Warning: mktime() [function.mktime]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 60

Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 61

Warning: date() [function.date]: It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EST/-5.0/no DST' instead in /var/www/custom/archive.cmdm/config.php on line 62

Deprecated: Function ereg_replace() is deprecated in /var/www/custom/archive.cmdm/article.php on line 102
不会产生氢气的可生物降解镁金属植入物 - China Medical Device Manufacturer
CMDM

- English | 中文

Fri, January 19th, 2018

2010年1月CMDM电子快讯 » 技术新知
不会产生氢气的可生物降解镁金属植入物

By: Shana Leonard


采用高频电流熔融制成的镁合金,适合用于可生物降解植入物。图片由LMPT/ETH苏黎世提供。
继成功研发出采用可生物降解聚合物材料的植入物之后,研究人员又开始尝试采用可生物降解的金属材料。镁具有杰出的机械稳定性和生物相容性,因而是可生物降解金属植入物的主要候选材料之一。但是镁有一个重要缺点阻碍其用于生产植入物:镁降解时会产生氢气,而这会延长愈合过程,进而可能对人体造成潜在危害。为解决上述问题,瑞士联邦理工学院(瑞士苏黎世,www.ethz.ch)的研究小组开发了一种镁金属玻璃,临床试验发现这种镁金属材料不会释放氢气。

这项广泛研究的重点在于开发一种能在体内完成既定功能之后,可以生物降解的植入物。这样可以免除利用外植手术取出植入物的需要,从而最大程度地减少因长期植入引起的常见疾病(例如炎症或者支架再狭窄)。

与采用聚合物的同类产品相比,诸如镁金属植入物具有更高的机械强度而且生物腐蚀后仅会释放惰性气体离子。但镁金属降解会在植入物周围形成氢气气泡,而这会延缓骨骼生长,甚至引发感染。

瑞士联邦理工大学金属物理和技术系教授Jrg Lffler及其同事经过长期研究,通过将混合锌与镁形成的镁锌合金玻璃,成功解决了上述问题。他表示,快速冷却工艺令这种材料具有更大的弹性。Lffler认为,相比窗玻璃,这种合金玻璃可通过迅速冷却熔融的金属材料形成非晶体结构,而不是像传统金属一样形成晶体结构。

“得益于这项工艺,我们才能在镁中加入比传统合金更多的锌,”Lffler解释说。“一旦合金中的锌原子超过28%,合金表面就会形成一种锌-氧绝缘层,这就从根本上改变了材料的腐蚀现象。”采用少量这种新型材料进行的临床试验显示其不会生成氢气。”

由于这种生物相容性金属玻璃不会产生氢气,因而可以用作新一代可生物降解植入物的主要原料。这种合金的厚度可达5 mm,可用作骨骼植入物,甚至血管支架。

版权所有 © 2005-2010 医疗设计和制造OEM (CMDM) 本网站所有内容,如未获书面同意,不得以任何形式转载和节录。违反上述声明者,我方将依法追究法律责任。

本期其他技术新知

相关文章

- 主页 | 当期杂志 | 订阅 | 联系方式 | 关于我们 -©2011 汇科传讯集团 医疗设计和制造OEM 版权所有.