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增强组织支架的骨细胞外基质共聚物模拟 - China Medical Device Manufacturer
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Fri, January 19th, 2018

2011年2月CMDM电子快讯 » 技术新知
增强组织支架的骨细胞外基质共聚物模拟

用于优化组织支架,由新加坡材料科学与工程研究所(IMRE A*STAR)研究人员开发的共聚物可以模拟骨细胞外基质的力学性能、表面化学性质、和人体骨细胞外基质的孔隙度。因此,这些材料特征可能会促进形成更多的支架组织。

为了实现这些理想的特性,研究人员修改了具有生物相容性,可生物降解的聚羟基丁酸酯(PHB)材料,这是由细菌所产生。通过将聚乙二醇(PEG)加入PHB骨干,科学家们能够改变PHB材料自然的脆性和疏水性,而展示其亲水性和延展性。测试表明,共聚物可以被拉紧至其原始长度的20倍。由此产生的聚合物纤维通过电纺丝过程被织成多孔结构。

研究人员表示,当被浸入模拟体液中时,那些以共聚物为基础的多孔支架能够吸收盐份,进行表面改性矿化,而无需对表面进行调整。 他们认为,这种能力有助于形成一种可以媲美天然骨的细胞外基质。

参加该项目的新加坡材料科学与工程研究所(IMRE A*STAR) 研究员李旭表示,“使用新型PHB–PEG共聚物制成的支架可能有助于骨生成,因此将改善骨质疏松症患者的生活质量。”

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