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植入物模仿松骨皮质 - China Medical Device Manufacturer
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Sun, December 17th, 2017

2011年8月CMDM电子快讯 » 技术新知
植入物模仿松骨皮质

韩国研究人员已经开发出一种生产松质骨和皮质骨植入物的技术。以往的研究都集中在生产松质骨,那是一种海绵形、蜂窝状结构。但是,实际应用的人工骨骼必须模仿皮质骨,哪种在骨外层的坚硬、强大的组织。通过模仿天然骨,人们希望植入材料能更好地补充自然再生过程。顺天乡大学医学院生物医学工程和材料系的Yang-Hee Kim 和Byong-Taek Lee的研究成果发表在本期《先进材料科技》(STAM)上。

松质骨比骨皮质更多孔,但它却包括了骨形成时营养流动的渠道。国家材料科学研究所(NIMS)在一份新闻稿中指出,通过开发模仿这个通道结构的过程,研究人员可在制造人工骨骼领域取得了显著进展。

此技术包括通过静电在直径约为0.3毫米的钢丝上静电包裹羟基磷灰石成分PMMA- PCL包装羟基磷灰石成分PMMA- PCL。生物聚合物束包含一个松质骨结构支架,该支架由对氧化锆(ZrO2)和双相磷酸钙(BCP)标准的海绵仿制法制成。去除钢丝后则显示了模仿小人体骨骼的相互关联的结构。

最终的结构具有高强度和大约70%孔隙率的特点。尽管测试显示的材料具备生物相容性,还需要进一步进行体外和体内研究,以全面评估其生物学特性。

人口老化使骨质流失和骨折成为主要的全球性问题,并促进骨再生的研究。仿生法制造人工植入物备受关注,但愈合过程对与植入材料相互作用的依赖需要仔细模仿天然骨结构。NIMS表示,本文标志着在制造人造骨骼结构过程中,材料和加工技术的发展方面的显著进步。

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